About Me

 

I am a Senior Health Economist at Health Quality Ontario (HQO), Toronto, Canada. My research interests include research methodology (e.g., the economic evaluation of diagnostic tests in the absence of a gold standard, non-inferiority trial frameworks for clinical decision-making and calibration), applied economic evaluations, meta-analysis, and health technology assessment (HTA). Prior to joining HQO, I worked as a Biostatistician at the Technology Assessment Unit (TAU) of McGill University Health Center in Montreal, and as a Health Economist at University of Toronto's Toronto Health Economics and Technology Assessment (THETA) Collaborative.

 

I completed his undergraduate study in Medicinal Chemistry at Beijing Medical University, China, and obtained a MSc degree in Public Health from the University of Southern Denmark, focusing on health economic evaluation.  

 

I created this web site to document some thoughts and take notes of my researches. I constantly update and improve this web. The entire contents of this web have not been peer-reviewed, and reflected my own academic opinions only.  I write SAS/R/Winbugs/VBA code for statistical analysis, plotting and data management in Windows System originally. Users can modify them, but without any warranty. If you find errors or you have suggestions of my web, please contact me. E-mail: shawn.xieq@gmail.com.

 

Peer review: I am a reviewer of articles for Canadian Medical Association Journal (CMAJ), Value in Health, BMJ Open, Am J Cardiovasc Drugs, International Journal of Health Policy and Management, International Journal of Stroke, Oncotarget, Open Medicine, Cancer Management and Research.

 

Statistical programming skills:
      

* Certified Advanced Programmer for SAS 9 in 2007, proficiency in SAS (SAS/STAT, SAS/BASE, SAS/SQL, SAS/MACROS, SAS/GRAPH, SAS/ODS, etc.)

* Proficiency in TREEAGE and Excel VBA in economic analysis

* Good knowledge of R, Winbug, Stata, Crystal Ball, Arena, I think, Review Manager, Microsoft Project, Microsoft Office, etc.

 


SELECTED PUBLICATIONS IN PEER-REVIEWED JOURNALS

Xie XYeung MW, Wang Z, Wang M, Gajic-Veljanoski O, Ng V, Volodin A. Comparison of the expected rewards between probabilistic and deterministic analyses in a Markov model. Expert Rev Pharmacoecon Outcomes Res. 2019 May 22:1-7 [Epub ahead of print] Link: https://www.ncbi.nlm.nih.gov/pubmed/31116609 

Xie X, Falk L, Brophy JM, Tu HA, Guo J, Gajic-Veljanoski O, Sikich N, Dhalla IA, Ng V. A non-inferiority framework for cost-effectiveness analysis. Int J Technol Assess Health Care. 2019;35(4):291-297 Link: https://www.ncbi.nlm.nih.gov/pubmed/31337452

Xie X, Sinclair A, Dendukuri N. Evaluating the accuracy and economic value of a new test in the absence of a perfect reference test. Res Synth Methods. 2017; 8(3):321-332 Link: https://www.ncbi.nlm.nih.gov/pubmed/28544646

Xie X, Wang M, Ng V, Sikich N. Some issues for the evaluation of noninferiority trials. J Comp Eff Res. 2018 Sep;7(9):835-843. Link: https://www.ncbi.nlm.nih.gov/pubmed/30192159

Xie X, Ye C, Mitsakakis N. The impact of the underlying risk in control group and effect measures in non-Inferiority trials with time-to-event data: a simulation study. J Clin Med Res. 2018 May;10(5):376-383. Link: https://www.ncbi.nlm.nih.gov/pubmed/29581799

Xie X, Wang M, Ng V, Volodin A. Calibrating Time-Dependent One-Year Relative Survival Ratio for Selected Cancers. Lobachevskii Journal of Mathematics. 2018 June; 39(5):722-729 Link of view-only version: https://rdcu.be/bIGxv

Xie X, Lambrinos A, Chan B, Dhalla IA, Krings T, Casaubon LK, Lum C, Sikich N, Bharatha A, Pereira VM, Stotts G, Saposnik G, O'Callaghan C, Kelloway L, Hill MD. Mechanical thrombectomy in patients with acute ischemic stroke: a cost-utility analysis. CMAJ Open. 2016; 4(2):E316-25 Link: http://www.ncbi.nlm.nih.gov/pubmed/27398380

Xie X, Vondeling H. Cost-utility analysis of intensive blood glucose control with metformin versus usual care in overweight type 2 diabetes mellitus patients in Beijing, P.R. China. Value Health 2008; 11 (Suppl):S23-S32 Link: http://www.ncbi.nlm.nih.gov/pubmed/18387063

Xie X, Dendukuri N, McGregor M. Percutaneous radiofrequency ablation for the treatment of early stage hepatocellular carcinoma: A Health Technology Assessment. Int J Technol Assess Health Care 2010; 26(4):390-7 Link: http://www.ncbi.nlm.nih.gov/pubmed/20923590

Xie X, Young J, Kost K, McGregor M. 532 nm KTP Laser for laryngeal lesions. A systematic review. J Voice. 2013; 27(2): 245-9 Link: http://www.ncbi.nlm.nih.gov/pubmed/23294705  

Xie X, McGregor M, Dendukuri N. The Clinical Effectiveness of Negative Pressure Wound Therapy. A systematic review. J Wound Care 2010; 19(11): 490-5  Link: http://www.ncbi.nlm.nih.gov/pubmed/21135797

Xie X. Some Suggestions on Clinical Study of Traditional Chinese Medicine, Chinese Journal of integrated traditional and western medicine. 2006, Vol. 26, No 5, 455-458 (in Chinese) Link: http://www.ncbi.nlm.nih.gov/pubmed/16883918 

Sinclair A, Xie X, Saab L, Dendukuri N. Lactobacillus probiotics in the prevention of diarrhea associated with Clostridium difficile: a systematic review and Bayesian hierarchical meta-analysis. CMAJ Open. 2016; 4(4):E706-E718. Link: https://www.ncbi.nlm.nih.gov/pubmed/28018885

Benmassaoud A, Xie X, AlYafi MM, Théorêt Y, Seidman EG, Bitton A, Afif W, Bessisso T. Thiopurines in the Management of Crohn's Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity-A Retrospective Study. Can J Gastroenterol Hepatol 2016; 2016:1034834. Link: http://www.ncbi.nlm.nih.gov/pubmed/27446822

Feifer A, Xie X, Brophy JM, Segal R, Kassouf W. Contemporary Cost Analysis of Single Instillation of Mitomycin after Transurethral Resection of Bladder Tumor in a Universal Health Care System. Urology 2010; 76(3): 652-7.  Link: http://www.ncbi.nlm.nih.gov/pubmed/20394970

Filion KB, Xie X, van der Avoort CJ, Dendukuri N, Brophy JM. Microvolt T-wave alternans and the selective use of implantable cardioverter defibrillators for primary prevention: a cost-effectiveness study. Int J Technol Assess Health Care 2009; 25(2):151-60 Link: http://www.ncbi.nlm.nih.gov/pubmed/19331707

Quenneville SP, Xie X, Brophy JM. The cost-effectiveness of Maze procedures using ablation techniques at the time of mitral valve surgery. Int J Technol Assess Health Care 2009; 25(4):485-96 Link: http://www.ncbi.nlm.nih.gov/pubmed/19818194

Sinclair A, Xie X, Teltscher M, Dendukuri D. A urine pneumococcal antigen test (BinaxNOW Streptococcus pneumoniae) for the diagnosis of community acquired Streptococcus pneumoniae pneumonia: Systematic review and meta-analysis. J Clin Microbiol. 2013; 51(7):2303-10. Link: http://www.ncbi.nlm.nih.gov/pubmed/23678060

Zheng J, Alsaadi T, Blaichman J, Xie X, Omeroglu A, Meterissian S, Mesurolle B. Invasive ductal carcinoma of the breast: correlation between tumor grade determined by ultrasound-guided core biopsy and surgical pathology. AJR Am J Roentgenol. 2013; 200(1):W71-4  Link: http://www.ncbi.nlm.nih.gov/pubmed/23255773

Sun S, Semionov A, Xie X, Kosiuk J, Mesurolle B. Detection of central pulmonary embolism on non-contrast computed tomography: a case control study. Int J Cardiovasc Imaging. 2014;30(3):639-46. Link: http://www.ncbi.nlm.nih.gov/pubmed/24390296

Mylotte D, Quenneville SP, Kotowycz MA, Xie X, Brophy JM, Ionescu-Ittu R, Martucci G, Pilote L, Therrien J, Marelli AJ. Long-term cost-effectiveness of transcatheter versus surgical closure of secundum atrial septal defect in adults. Int J Cardiol. 2014; 172(1):109-14. Link:  http://www.ncbi.nlm.nih.gov/pubmed/24485223

Mesurolle B, Perez JC, Azzumea F, Lemercier E, Xie X, Aldis A, Omeroglu A, Meterissian S. Atypical ductal hyperplasia diagnosed at sonographically guided core needle biopsy: frequency, final surgical outcome, and factors associated with underestimation. AJR Am J Roentgenol. 2014;202(6):1389-94. Link: http://www.ncbi.nlm.nih.gov/pubmed/24848840

 

Selected HTA reports for HQO and TAU, McGill:

Health Quality Ontario. Noninvasive prenatal testing for trisomies 21, 18, and 13, sex chromosome aneuploidies, and microdeletions: a health technology assessment. Ont Health Technol Assess Ser [Internet]. 2019 Feb;19(4):1166. Available from: http://www.hqontario.ca/evidence-to-improve-care/journal-ontario-health-technology-assessment-series (Xie X was the Lead Health Economist for this report.)

Health Quality Ontario. Robot-Assisted Radical Prostatectomy: A Health Technology Assessment. Ont Health Technol Assess Ser [Internet]. 2017 ;17(11):1-172. Available from: http://www.hqontario.ca/Portals/0/Documents/evidence/reports/hta-prostatectomy-1707-en.pdf (Xie X was the Lead Health Economist for this report.)

Health Quality Ontario. Composite tissue transplant of hand or arm: a health technology assessment. Ont Health Technol Assess Ser [Internet]. 2016 June;16(13):1-70. Available from: http://www.hqontario.ca/Portals/0/documents/evidence/reports/hta-limb-transplant-en-1606.pdf (Xie X was the Health Economist for this report.)

Health Quality Ontario. Mechanical thrombectomy in patients with acute ischemic stroke: a health technology assessment. Ont Health Technol Assess Ser [Internet]. 2016 February;16(4):1-79. Available from: http://www.hqontario.ca/Portals/0/Documents/evidence/reports/hta-mechanical-thrombectomy-1602-en.pdf (Xie X was the Health Economist for this report.)

Xie X, Wang M, Schaink A, Krahn M. Pulmonary rehabilitation for postacute exacerbations of chronic obstructive pulmonary disease (COPD): a cost-effectiveness and budget impact analysis [Internet]. Toronto: Queen’s Printer for Ontario; 2015. 47 p. Available from: http://www.hqontario.ca/evidence/publications-and-ohtac-recommendations/other-reports/special-reports

Xie X, Rich B, Dendukuri N. Islet Cell Transplantation in patients with Type 1 Diabetes Mellitus. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2014. Report no. 66. 72 p. Available from: http://www.mcgill.ca/tau/files/tau/muhc_tau_2014_66_islet_transplantation.pdf  

Xie X, Nicolau I, McGregor M, Dendukuri N. Subglottic secretion drainage endotracheal tubes for prevention of ventilator-associated pneumonia. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2011 Dec 21. Report no. 56. 38 p. Available from: http://www.mcgill.ca/tau/files/tau/muhc_tau_2011_56_ssd.pdf

Xie X, McGregor M. Video capsule endoscopy for obscure GI bleeding and Crohn’s disease (Update to Report 7). Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2012 Jun 13. Report no. 60. 38 p. Available from:

http://www.mcgill.ca/tau/files/tau/muhc_tau_2012_60_vce.pdf

Xie X, Dendukuri N, McGregor M. Single-dose Intraoperative Radiotherapy Using Intrabeam® for Early stage Breast cancer: A Health Technology Assessment. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2012 October 30. Report no. 63. 28 p. Available from:  http://www.mcgill.ca/tau/files/tau/muhc_tau_2012_63_intrabeam.pdf

Xie X, McGregor M. Negative Pressure wound therapy (NPWT): update of report 19. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2010. Report no. 48. 49 p. Available from: http://www.mcgill.ca/tau/files/tau/NPWT_FINAL.pdf

Xie X, McGregor M, Dendukuri N. Radiofrequency ablation for treatment of Barrett’s esophagus: A systematic review and cost analysis. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2009. Report no. 46. 37p. Available from: http://www.mcgill.ca/tau/files/tau/BARRETTs_ESOPHAGUS_REPORT.pdf

Xie X, Dendukuri N, McGregor M. Percutaneous Radiofrequency Ablation for treatment of hepatocellular carcinoma. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2009. Report no. 39. 61p. Available from: http://www.mcgill.ca/tau/files/tau/RFA_and_Liver_Cancer_FINAL.pdf

 

Complete publications list by year (articles in journal, HTA reports, abstracts and poster or oral presentations)

2019

Peer-reviewed Journal

Xie X, Yeung MW, Wang Z, Wang M, Gajic-Veljanoski O, Ng V, Volodin A. Comparison of the expected rewards between probabilistic and deterministic analyses in a Markov model. Expert Rev Pharmacoecon Outcomes Res. 2019 May 22:1-7 [Epub ahead of print] Link: https://www.ncbi.nlm.nih.gov/pubmed/31116609 

Xie X, Falk L, Brophy JM, Tu HA, Guo J, Gajic-Veljanoski O, Sikich N, Dhalla IA, Ng V. A non-inferiority framework for cost-effectiveness analysis. Int J Technol Assess Health Care. 2019;35(4):291-297 Link: https://www.ncbi.nlm.nih.gov/pubmed/31337452

HQO report

Health Quality Ontario. Noninvasive prenatal testing for trisomies 21, 18, and 13, sex chromosome aneuploidies, and microdeletions: a health technology assessment. Ont Health Technol Assess Ser [Internet]. 2019 Feb;19(4):1166. Available from: http://www.hqontario.ca/evidence-to-improve-care/journal-ontario-health-technology-assessment-series (Xie X was the Lead Health Economist for this report.)

 

2018

Peer-reviewed Journal

Xie X, Wang M, Ng V, Sikich N. Some issues for the evaluation of noninferiority trials. J Comp Eff Res. 2018 Sep;7(9):835-843. Link: https://www.ncbi.nlm.nih.gov/pubmed/30192159

Xie X, Ye C, Mitsakakis N. The impact of the underlying risk in control group and effect measures in non-Inferiority trials with time-to-event data: a simulation study. J Clin Med Res. 2018 May;10(5):376-383. Link: https://www.ncbi.nlm.nih.gov/pubmed/29581799

Xie X, Wang M, Ng V, Volodin A. Calibrating Time-Dependent One-Year Relative Survival Ratio for Selected Cancers. Lobachevskii Journal of Mathematics. 2018 June; 39(5):722-729 Link of view-only version: https://rdcu.be/bIGxv

Gajic-Veljanoski O, Sanyal C, McMartin K, Xie X, Walter M, Higgins C, Sikich N, Dhalla IA, Ng V. Economic evaluations of commonly used structured psychotherapies for major depressive disorder and generalized anxiety disorder: A systematic review. Canadian Psychology/Psychologie Canadienne. 2018; 59(4), 301-314. Link: https://psycnet.apa.org/record/2018-55269-002

 

2017

Peer-reviewed Journal

Xie X, Sinclair A, Dendukuri N. Evaluating the accuracy and economic value of a new test in the absence of a perfect reference test. Res Synth Methods. 2017; 8(3):321-332 Link: https://www.ncbi.nlm.nih.gov/pubmed/28544646

HQO report

Health Quality Ontario. Home-Based Subcutaneous Infusion of Immunoglobulin for Primary and Secondary Immunodeficiencies: A Health Technology Assessment. Ont Health Technol Assess Ser [Internet]. 2017; 17(16):1-86. Available from: http://www.hqontario.ca/Portals/0/documents/evidence/reports/hta-ig-home-infusion-1711.pdf (Xie X was the Lead Health Economist for this report.)

Health Quality Ontario. Robot-Assisted Radical Prostatectomy: A Health Technology Assessment. Ont Health Technol Assess Ser [Internet]. 2017; 17(11):1-172. Available from: http://www.hqontario.ca/Portals/0/Documents/evidence/reports/hta-prostatectomy-1707-en.pdf (Xie X was the Lead Health Economist for this report.)

Health Quality Ontario. Percutaneous Ventricular Assist Devices: A Health Technology Assessment. Ont Health Technol Assess Ser [Internet]. 2017 ;17(2):1-97. Available from: http://www.hqontario.ca/Evidence-to-Improve-Care/Journal-Ontario-Health-Technology-Assessment-Series (Xie X was the second Health Economist for this report.)

Abstract and poster/oral presentation

Poster presentation in ISPOR 2017 (May 20 to 24, 2017; Boston) and Abstract: Xie X, Li C, Wang M, Higgins C, Sikich N, Dhalla I, Ng V. Robotic Surgical System for Radical Prostatectomy: a Cost-Utility Analysis. Value Health 2017; 20 Suppl: A112

Abstract: Tu HA, Xie X, Sikich N, Dhalla I, Ng V. Cost-effectiveness of Argus II Retinal Prosthesis System for Advanced Retinitis Pigmentosa. Value Health 2017; 20 Suppl: A248

Abstract: Djalalov S, Xie X, Wijeysundera H.C, Sikich N, Dhalla I, Ng V. Cost-effectiveness of Percutaneous Ventricular Assist Devices for High-Risk PCI Patients in Ontario, Canada. Value Health 2017; 20 Suppl: A248

Abstract: Li C, Schaink A K, Xie X, Holubowich C, Sikich N, Dhalla I, Ng V. Budget Impact Analysis of the Cell Cycle Progression Test in Low and Intermediate Risk, Localized Prostate Cancer. Value Health 2017; 20 Suppl: A240

Abstract: Tu HA, Costa V, Xie X, Wijeysundera H.C, Sikich N, Dhalla I, Ng V. Cost-effectiveness of Fibreglass Total Contact Casting, Irremovable Cast Walkers and Removable Cast Walkers in the Treatment of Patients with Diabetic Foot Ulcers in Ontario, Canada. Value Health 2017; 20 Suppl: A242

Abstract: Tu HA, Wijeysundera H. C, Sehatzadeh S, Xie X, Sikich N, Dhalla I, Ng V. Cost-effectiveness of Transcatheter Aortic Valve Implantation compared with Surgical Aortic Valve Implantation in High Surgical Risk Patients With Severe Aortic Stenosis in Ontario, Canada.

 

2016

Peer-reviewed Journal

Xie X, Lambrinos A, Chan B, Dhalla IA, Krings T, Casaubon LK, Lum C, Sikich N, Bharatha A, Pereira VM, Stotts G, Saposnik G, O'Callaghan C, Kelloway L, Hill MD. Mechanical thrombectomy in patients with acute ischemic stroke: a cost-utility analysis. CMAJ Open. 2016; 4(2):E316-25 Link: http://www.ncbi.nlm.nih.gov/pubmed/27398380

Sinclair A, Xie X, Saab L, Dendukuri N. Lactobacillus probiotics in the prevention of diarrhea associated with Clostridium difficile: a systematic review and Bayesian hierarchical meta-analysis. CMAJ Open. 2016; 4(4):E706-E718. Link: https://www.ncbi.nlm.nih.gov/pubmed/28018885

Benmassaoud A, Xie X, AlYafi MM, Théorêt Y, Seidman EG, Bitton A, Afif W, Bessisso T. Thiopurines in the Management of Crohn's Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity-A Retrospective Study. Can J Gastroenterol Hepatol. 2016; 2016:1034834. Link: http://www.ncbi.nlm.nih.gov/pubmed/27446822

Lambrinos A, Schaink AK, Dhalla IA, Krings T, Casaubon LK, Sikich N, Lum C, Bharatha A, Pereira VM, Stotts G, Saposnik G, Kelloway L, Xie X, Hill MD. Mechanical Thrombectomy in Acute Ischemic Stroke: A Systematic Review. Can J Neurol Sci. 2016;43(4):455-60 Link: https://www.ncbi.nlm.nih.gov/pubmed/27071728

HQO report

Health Quality Ontario. Composite tissue transplant of hand or arm: a health technology assessment. Ont Health Technol Assess Ser [Internet]. 2016 June;16(13):1-70. Available from: http://www.hqontario.ca/Portals/0/documents/evidence/reports/hta-limb-transplant-en-1606.pdf (Xie X was the Lead Health Economist for this report.)

Health Quality Ontario. Mechanical thrombectomy in patients with acute ischemic stroke: a health technology assessment. Ont Health Technol Assess Ser [Internet]. 2016 February;16(4):1-79. Available from: http://www.hqontario.ca/Portals/0/Documents/evidence/reports/hta-mechanical-thrombectomy-1602-en.pdf (Xie X was the Lead Health Economist for this report.)

Abstract and poster/oral presentation

Poster: Xie X, Lambrinos A, Chan B, Sikich N, Dhalla IA. Mechanical thrombectomy in patients with acute ischemic stroke: a health technology assessment. Canadian Association for Health Services and Policy Research (CAHSPR) 2016 (May 10 to 12, 2016; Toronto)

Poster: Xie X, Lambrinos A, Tu HA, Pron G, Higgins C, Ng V, Composite tissue transplantation for hand or arm: a health technology assessment. Canadian Association for Health Services and Policy Research (CAHSPR) 2016 (May 10 to 12, 2016; Toronto)

Oral Presentation, presented by Tu HA: Tu HA, Xie X, Holubowich C, Weir M, Dhalla IA, Sikich N. Cost-effectiveness of Argus II Retinal Prosthesis System for Advanced Retinitis Pigmentosa. Canadian Association for Health Services and Policy Research (CAHSPR) 2016 (May 10 to 12, 2016; Toronto)

 

2015

HQO report

Xie X, Wang M, Schaink A, Krahn M. Pulmonary rehabilitation for postacute exacerbations of chronic obstructive pulmonary disease (COPD): a cost-effectiveness and budget impact analysis [Internet]. Toronto: Queen’s Printer for Ontario; 2015. 47 p. Available from: http://www.hqontario.ca/evidence/publications-and-ohtac-recommendations/other-reports/special-reports

Abstract and poster/oral presentation

Xie X, Abrahamyan L, Tawfik A, Kabali C, Pham B, Krahn M. Cost-Utility Analysis of Robotic-Assisted versus Open Radical Prostatectomy in Patients with Clinically Localized Prostate Cancer in Ontario. Canadian Association for Health Services and Policy Research (CAHSPR) 2015 (May 26 to 28, 2015; Montreal)

Xie X, Wang M, Schaink A, Krahn M. Pulmonary Rehabilitation for Post-Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Cost-Effectiveness and Budget Impact Analysis. The Canadian Agency for Drugs and Technologies in Health (CADTH) Symposium 2015 (April 12 to 14, 2015; Saskatoon)

Xie X, Rich B, Dendukuri N. Cost effectiveness analysis of islet transplantation in patients with Type 1 Diabetes Mellitus. The Canadian Agency for Drugs and Technologies in Health (CADTH) Symposium 2015 (April 12 to 14, 2015; Saskatoon)

 

2014

Peer-reviewed Journal

Sun S, Semionov A, Xie X, Kosiuk J, Mesurolle B. Detection of central pulmonary embolism on non-contrast computed tomography: a case control study. Int J Cardiovasc Imaging. 2014;30(3):639-46. Link: http://www.ncbi.nlm.nih.gov/pubmed/24390296

Mylotte D, Quenneville SP, Kotowycz MA, Xie X, Brophy JM, Ionescu-Ittu R, Martucci G, Pilote L, Therrien J, Marelli AJ. Long-term cost-effectiveness of transcatheter versus surgical closure of secundum atrial septal defect in adults. Int J Cardiol. 2014; 172(1):109-14. Link:  http://www.ncbi.nlm.nih.gov/pubmed/24485223

Mesurolle B, Perez JC, Azzumea F, Lemercier E, Xie X, Aldis A, Omeroglu A, Meterissian S. Atypical ductal hyperplasia diagnosed at sonographically guided core needle biopsy: frequency, final surgical outcome, and factors associated with underestimation. AJR Am J Roentgenol. 2014;202(6):1389-94. Link: http://www.ncbi.nlm.nih.gov/pubmed/24848840

McGill HTA report

Xie X, Rich B, Dendukuri N. Islet Cell Transplantation in patients with Type 1 Diabetes Mellitus. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2013. Report no. 66. 72 p. Available from: http://www.mcgill.ca/tau/files/tau/muhc_tau_2014_66_islet_transplantation.pdf
MUHC TAU Members (Contributors: Xie X, Sinclair A, Dendukuri N). Economic Analyses for Health Technology Assessment Unit (TAU) reports: A Manual, version 1.0. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); August 26, 2014 (internal report). 

Abstract and poster/oral presentation

Benmassaoud A, Xie X, AlYafi MM, Théorêt Y, Seidman EG, Bitton A, Afif W, Bessisso T. Thiopurines in the Management of Crohn's Disease: Safety and Efficacy Profile in Patients With Intermediate and Normal Thiopurine Methyltransferase Activity, a Retrospective Study. Gastroenterology. 2014; 146(5), Supplement 1, S-4634 (It was presented by Benmassaoud A.)

 

2013

Peer-reviewed Journal

Sinclair A, Xie X, Teltscher M, Dendukuri D. A urine pneumococcal antigen test (BinaxNOW Streptococcus pneumoniae) for the diagnosis of community acquired Streptococcus pneumoniae pneumonia: Systematic review and meta-analysis. J Clin Microbiol. 2013; 51(7):2303-10. Link: http://www.ncbi.nlm.nih.gov/pubmed/23678060 (Based on McGill HTA report: 57)

Xie X, Young J, Kost K, McGregor M. 532 nm KTP Laser for laryngeal lesions. A systematic review. J Voice. 2013; 27(2): 245-9 Link: http://www.ncbi.nlm.nih.gov/pubmed/23294705   (This paper was based on McGill HTA report: 61)

Zheng J, Alsaadi T, Blaichman J, Xie X, Omeroglu A, Meterissian S, Mesurolle B. Invasive ductal carcinoma of the breast: correlation between tumor grade determined by ultrasound-guided core biopsy and surgical pathology. AJR Am J Roentgenol. 2013; 200(1):W71-4  Link: http://www.ncbi.nlm.nih.gov/pubmed/23255773

McGill HTA report

Sinclair A, Xie X, McGregor MM. Transcatheter aortic valve implantation (TAVI) in patients with aortic stenosis: Update of Report 45. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2013.  Report no. 70. 48p. Available from:

http://www.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2013_70_tavi.pdf

Sinclair A, Xie X, McGregor MM. Surgical aortic valve replacement with the ATS Enable sutureless aortic valve for aortic stenosis. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2013. Report no. 71. 27p. Available from:

http://www.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2013_71_suavr_a.pdf 

SinclairA, Nicolau I, Xie X, Nandini Dendukuri. The effectiveness and safety of rituximab (anti-CD20) in neurologic autoimmune diseases. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2013. Report no. 64. 79p. Available from: http://www.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2013_64_rituximab.pdf

MUHC TAU Members (Contributors: Sinclair A, Nicolau I, Xie X, Dendukuri N, Brophy J, McGregor M). Guidelines for systematic literature search, version 2.0. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2013. 17 p. Available from:
http://www.mcgill.ca/tau/files/tau/muhc_tau_search_v2.0.pdf

Abstract and poster/oral presentation

Oral presentation: Babaei S, Peltz J, Rafat Zand K, Xie X, Taylor J. Adequacy of CT Aortograms in the Detection of Pulmonary Emboli. 23rd Annual Research day. Department of diagnostic radiology, McGill University. Intercontiental Hotel, Montreal. April 13 2013. (Original research. It was presented by Babaei S.)

 

2012

Peer-reviewed Journal

Xie X. Fundamental Issues for Sustainable Development of the New Rural Cooperative Medical System in China. Accepted by Chinese Health Service Management. 2012; 29 (suppl): S74-7 (in Chinese)  

McGill HTA report

Xie X, McGregor M. 532 nm KTP Laser for vocal fold surgery. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2012 Apr 24. Report no. 61. 26 p. Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2012_61_ktp_a.pdf

Xie X, McGregor M. Video capsule endoscopy for obscure GI bleeding and Crohn’s disease (Update to Report 7) Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2012 Jun 13. Report no. 60. 38 p. Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2012_60_vce.pdf

Xie X, Dendukuri N, McGregor M. Single-dose Intraoperative Radiotherapy Using Intrabeam® for Early stage Breast cancer: A Health Technology Assessment. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2012 October 30. Report no. 63. 28 p. Available from:

 http://www.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2012_63_intrabeam.pdf

Nicolau I, Xie X, McGregor M and Dendukuri N. Evaluation of Acellular Dermal Matrix for Breast Reconstruction: An Update. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2012 June 4. Report no. 59. 42p. Available from: http://www.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2012_59_dermalmatrix.pdf

Nicolau I, Pan I, Xie X, McGregor M, Dendukuri N. Drotrecogin alfa (activated) in severe sepsis: a systematic review of observational studies. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2012 Jul 25. Report no. 58. 18 p. Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2012_58_sepsis.pdf

McGregor M and Xie X. Hyaluronic Acid Fat Graft Myringoplasty or Epidisk Tympanoplasty (ET).Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); MiniHTA: 2012 Aug 29. Report no. 69. 4 p. Available from: http://www.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2012_69_epidisk.pdf

Abstract and poster/oral presentation

Poster: Xie X, Nicolau I, McGregor M, Dendukuri N. Evidence supports use of subglottic secretion drainage endotracheal tubes for prevention of ventilator-associated pneumonia. The Canadian Agency for Drugs and Technologies in Health (CADTH) Symposium 2012 (April 15 to 17, 2012; Ottawa)

Poster: Sinclair A, Xie X, Dendukuri N. Can a urine antigen test improve diagnosis of community acquired pneumonia and increase use of targeted antibiotics? A systematic review of the evidence. The Canadian Agency for Drugs and Technologies in Health (CADTH) Symposium 2012 (April 15 to 17, 2012; Ottawa)

Abstract: Hidalgo J, Lemercier E, Xie X, Xia S, Meterissian S, Mesurolle B. Underestimation of Atypical Ductal Hyperplasia (ADH) at Core Biopsy of the Breast (It was presented by Juan Hidalgo in the Radiological Society of North America (RSNA) conference in 2012.)

 

2011:

McGill HTA report

Xie X, Nicolau I, McGregor M, Dendukuri N. Subglottic secretion drainage endotracheal tubes for prevention of ventilator-associated pneumonia. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2011 Dec 21. Report no. 56. 38 p. Available from: https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_20 11_56_SSD.pdf

Sinclair A, Xie X, Dendukuri N. The clinical effectiveness and cost of a pneumococcal urine antigen immunochromatographic test (BinaxNOW Streptococcus pneumoniae) in the diagnosis of community acquired Streptococcus pneumoniae pneumonia in patients admitted to hospital. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2012 Jan 31. Report no. 57. 58 p. Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2011_57_binaxnow.pdf

Sinclair A, Xie X, Dendukuri N. The Use of Lactobacillus probiotics in the Prevention of Antibiotic Associated Clostridium Difficile Diarrhea. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2011 Dec 19. Report no. 54. 45 p. Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2011_ 54_probiotic.pdf

Xie X, McGregor M. Use of VerifyNow point of care test to detect non-responsiveness to clopidogrel and aspirin. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); MiniHTA: 2011 Jul 19. Report no. 53. 8 p. Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2011_53_verifynow_a.pdf

Dendukuri N, Xie X, McGregor M. Fiducial markers for improving treatment margins in radiotherapy for prostate cancer. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); MiniHTA: 2011 Jun 16. Report no. 52. 6 p. Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/muhc_tau_2011_52_fm_a.pdf

Abstract and poster/oral presentation

Poster: Xie X, McGregor M, Dendukuri N. Negative Pressure Wound Therapy. Is it effective? The Canadian Agency for Drugs and Technologies in Health (CADTH) Symposium 2011 (April 3 to 5, 2011; Vancouver)

Poster: Sinclair A, Xie X, Dendukuri N. Insufficient evidence of benefit associated with probiotic Lactobacillus for prevention of Clostridium Difficile diarrhea according to a Bayesian credibility analysis. The Canadian Agency for Drugs and Technologies in Health (CADTH) Symposium 2011 (April 3 to 5, 2011; Vancouver)

Oral presentation presented by Dr. McGregor: McGregor M, Xie X, Dendukuri N. The Use of Quality Instruments to Weight the Evidence obtained from Randomized Controlled Trials (RCTs). The Canadian Agency for Drugs and Technologies in Health (CADTH) Symposium 2011 (April 3 to 5, 2011; Vancouver)

Abstract: Quenneville SP, Xie X, Brophy JM, Kotowycz MA, Pilote L, Therrien J, Ionescu-Ittu R,  Martucci G, Marelli AJ. Cost Effectiveness of Transcatheter versus Surgical Closure of Secundum Atrial Septal Defect in Adults: A Population-Based Analysis. J Am Coll Cardiol.2011; 57: E461.

Abstract: Zheng J, Alsaadi T, Blaichman J, Xie X, Omeroglu A, Meterissian S, Mesurolle B. Invasive Ductal Carcinoma of the Breast: Correlation Between Tumor Grade of Ultrasound-Guided Core Biopsy and Surgical Pathology After Therapeutic Resection. (Presented by Jiamin Zheng in the Radiological Society of North America (RSNA) conference in 2011.)

 

2010

Peer-reviewed Journal

Xie X, McGregor M, Dendukuri N. The Clinical Effectiveness of Negative Pressure Wound Therapy. A systematic review. J Wound Care 2010; 19(11): 490-5  Link: http://www.ncbi.nlm.nih.gov/pubmed/21135797 (This paper was based on McGill HTA report No: 48.)

Xie X, Dendukuri N, McGregor M. Percutaneous radiofrequency ablation for the treatment of early stage hepatocellular carcinoma: A Health Technology Assessment. Int J Technol Assess Health Care 2010; 26(4):390-7 Link: http://www.ncbi.nlm.nih.gov/pubmed/20923590 (This paper was based on McGill HTA report No: 39.)

Feifer A, Xie X, Brophy JM, Segal R, Kassouf W. Contemporary Cost Analysis of Single Instillation of Mitomycin after Transurethral Resection of Bladder Tumor in a Universal Health Care System. Urology 2010; 76(3): 652-7.  Link: http://www.ncbi.nlm.nih.gov/pubmed/20394970  (The abstract of this article also published in CUAJ 2009; 3(Suppl 1): S38) 

McGill HTA report

Xie X, McGregor M. Negative Pressure wound therapy (NPWT): update of report 19. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2010. Report no. 48. 49 p. Available from: https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/NPWT_FINAL.pdf

Sinclair A, McGregor M, Xie X. Aortic valve bypass (apicoaortic conduit) in adult degenerative aortic stenosis. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2010. Report no. 50. 45p. Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/AorticValveBypass_FINAL.pdf

 

2009

Peer-reviewed Journal

Quenneville SP, Xie X, Brophy JM. The cost-effectiveness of Maze procedures using ablation techniques at the time of mitral valve surgery. Int J Technol Assess Health Care 2009; 25(4):485-96 Link: http://www.ncbi.nlm.nih.gov/pubmed/19818194

Filion KB, Xie X, van der Avoort CJ, Dendukuri N, Brophy JM. Microvolt T-wave alternans and the selective use of implantable cardioverter defibrillators for primary prevention: a cost-effectiveness study. Int J Technol Assess Health Care 2009; 25(2):151-60 Link: http://www.ncbi.nlm.nih.gov/pubmed/19331707 (The abstract of this article also published in Can J Cardiol 2008; 24(Suppl E): 330E)

McGill HTA report

Xie X, McGregor M, Dendukuri N. Radiofrequency ablation for treatment of Barrett’s esophagus: A systematic review and cost analysis. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2009. Report no. 46. 37p. Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/BARRETTs_ESOPHAGUS_REPORT.pdf

Xie X, McGregor M, Dendukuri N. The use of probiotics in the prevention and treatment of Clostridium Difficile diarrhea: An Update. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2009. Report no. 44. 18p. Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/PROBIOTICS_REPORT.pdf

Xie X, Dendukuri N, McGregor M. Percutaneous Radiofrequency Ablation for treatment of hepatocellular carcinoma. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2009. Report no. 39. 61p. Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/RFA_and_Liver_Cancer_FINAL.pdf

Abstract and poster/oral presentation

Poster: Xie X, Dendukuri N, McGregor M. Coblation Tonsillectomy in Pediatric Patients, The Canadian Agency for Drugs and Technologies in Health (CADTH) Symposium 2009 (April 6 to 9, 2009; Ottawa)

Oral presentation: Measuring cost-effectiveness: Incremental Cost Effectiveness Ratio vs. Net Benefit”. (Xie X. and Dendukuri N jointly presented in the meeting of Health Technology Assessment Unit, McGill University Health Centre (November 17, 2009; Montreal)

 

2008

Peer-reviewed Journal

Xie X, Vondeling H. Cost-utility analysis of intensive blood glucose control with metformin versus usual care in overweight type 2 diabetes mellitus patients in Beijing, P.R. China. Value Health 2008; 11 Suppl 1:S23-S32 Link: http://www.ncbi.nlm.nih.gov/pubmed/18387063

 

McGill HTA report

Xie X, Dendukuri N, McGregor M. Comparison of Coblation Tonsillectomy and Electrocautery Tonsillectomy in Pediatric Patients. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2008. Report no. 34. 28p. Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/Coblation_ND_MMG_LFM_Final.pdf

Xie X, Brophy JM. EZ-IO for intraosseous access. Montreal (Canada): Technology Assessment Unit (TAU) of the McGill University Health Centre (MUHC); 2008. (Informal brief report). Available from:

https://secureweb.mcgill.ca/tau/sites/mcgill.ca.tau/files/Brief_report_EZIO.pdf

Abstract and poster/oral presentation

Poster: Xie X, Vondeling H. metformin for overweight type 2diabetes, Annual meeting HTAi (health technology assessment international) 2008 (July 6 to 9, 2008; Montreal)

 

2006

Publications in Chinese journals

Xuanqian Xie. Some fundamental works before establishing national health insurance, Health Policy, 2006, No.198, 27-31 (in Chinese) Link: http://lib.cqvip.com/qk/96887A/200609/22748230.html

Xuanqian Xie. Why The Prevention Strategies are in Low Priority? The Journal of Nanjing Medical University. 2006, Vol. 20, No 2, 70-73 Link: http://d.wanfangdata.com.cn/Periodical_njykdxxb-e200602002.aspx

Xuanqian Xie. Hospital Management in new era can refer to “Clan” Culture. Chinese Hospital Management, 2006, Vol. 26, No 2, 59-60. (in Chinese) Link: http://d.wanfangdata.com.cn/Periodical_zgyygl200602022.aspx

Xuanqian Xie. Some Suggestions on Clinical Study of Traditional Chinese Medicine, Chinese Journal of integrated traditional and western medicine. 2006, Vol. 26, No 5, 455-458 (in Chinese) Link: http://www.ncbi.nlm.nih.gov/pubmed/16883918  http://d.wanfangdata.com.cn/Periodical_zxyjh200605018.aspx

Xuanqian Xie. Some suggestions of choosing control group in Clinical Study of Traditional Chinese Medicine, Traditional Chinese Medicine Research. 2006, Vol. 19, No 5, 1-2 (in Chinese) Link: http://d.wanfangdata.com.cn/Periodical_zyyj200605001.aspx

Xuanqian Xie. The Introduction of “The New Public Health”. Henan Journal of Preventive Medicine, 2006, Vol. 17, No 2,128-129. (in Chinese) Link: http://d.wanfangdata.com.cn/Periodical_hnyfyxzz200602032.aspx

Xuanqian Xie. The abbreviated translation of “Aschengrau A & Seage G.R. (2003) Critical Review of Epidemiologic Studies, Essentials of epidemiology in Public Health. Jones and Bartlett Publishers, Sudbury, MA. 348-359” was published in Chinese Journal of School Doctors, 2006 Vol. 20, No. 1. (in Chinese) Link: http://d.wanfangdata.com.cn/Periodical_zgxy200601064.aspx

 

2005

Publications in Chinese journals

Xuanqian Xie. Some Difficulties in Controlling the Increasing Health Expenditures. Health Policy, 2005, No.187, 24-26 (in Chinese) Link: http://lib.cqvip.com/qk/96887A/200510/20388698.html

Xuanqian Xie. Some Suggestions of Macro Drug Policy in China, Health Policy, 2005, No.181, 20-22 (in Chinese) Link: http://lib.cqvip.com/qk/96887A/200504/15448183.html

Xuanqian Xie. Some Problems Need to be Attention in Data Analysis by the Local Health Workers, Chinese Rural Health Service Administration, 2005, Vol. 25, No.12, 70-71 (in Chinese) Link: http://d.wanfangdata.com.cn/Periodical_zgncwssygl200512037.aspx

 

Before 2000

Publications in Chinese journals:

Xuanqian Xie, Yan Li. Retrospective Study on Pollution Accidents for Water-Resupply in High-Buildings in Beijing. China Public Health, 1999, Vol.15 No.12, 1106-1107 (in Chinese)

Xuanqian Xie. Study on Reasons of Water-Resupply Pollution Accidents and Preventive Procedures. Chinese Primary Health Care, 1999, Vol.13, No.160, September, 34 (in Chinese)

Xuanqian Xie, Yan Li. Preventive Sanitary Supervision should be strengthened in “to be built” Residential Regions. Chinese Health Policy, Vol.107, March 1999, 29 (in Chinese)

Xuanqian Xie. Effect on People's Health of Bottle-packed Mineral Water and Drinking Water Products. Chinese Primary Health Care, 1999, Vol.13 No.153, supplement, 248-250 (in Chinese)

 

Book:

Xuanqian Xie, Xin Lin. Lucky and Unlucky Cloning, Harbin Engineering University Press, 1997 (in Chinese)

 

Translation:

Five articles (3 long, 2 abstract) was published by a journal, “Overseas Preventive Medicine” from 1997 to 1999.

 

Articles published in newspapers:

I published nearly 20 articles in Chinese, whose topics varied from vaccines and pasteurization to food and drinking water, on popular Chinese newspapers such as Health News, Health Consultant News, Fitness times, and China Medical and Medicinal News.